Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells
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چکیده
منابع مشابه
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B stage. A subsequent functional light chain (LC) rearrangement then results in the surface expression of IgM at the immature B cell stage. Here we show that interruption of basal IgM signaling in immatur...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2005
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0030082